Additionally, phosphatidylethanolamine plays a role in the secretion of lipoproteins in the liver. When blood flow to the heart is restricted, the asymmetrical distribution of phosphatidylethanolamine between membrane leaflets is disrupted, and as a result the membrane is disrupted. In humans, metabolism of phosphatidylethanolamine is thought to be important in the heart. Lower melting temperatures correspond, in a simplistic view, to more fluid membranes. If the lipids had two palmitoyl chains, phosphatidylethanolamine would melt at 63 ☌ while phosphatidylcholine would melt already at 41 ☌. For example, the melting temperature of di-oleoyl-phosphatidylethanolamine is -16 ☌ while the melting temperature of di-oleoyl-phosphatidylcholine is -20 ☌. Īs a polar head group, phosphatidylethanolamine creates a more viscous lipid membrane compared to phosphatidylcholine. Phosphatidylethanolamine is an important precursor, substrate, or donor in several biological pathways. Additionally, it is thought that phosphatidylethanolamine regulates membrane curvature. Phosphatidylethanolamines play a role in membrane fusion and in disassembly of the contractile ring during cytokinesis in cell division. In human physiology, they are found particularly in nervous tissue such as the white matter of brain, nerves, neural tissue, and in spinal cord, where they make up 45% of all phospholipids. Phosphatidylethanolamines are found in all living cells, composing 25% of all phospholipids. The major membrane lipids: phosphatidylcholine (PtdCho) phosphatidylethanolamine (PtdEtn) phosphatidylinositol (PtdIns) phosphatidylserine (PtdSer).
0 kommentar(er)
